- Sandwich Shop Restaurants, Franklin
- Savings & Loan Associations, Franklin
- Savings Banks, Franklin
- Screen Printing, Franklin
- Seafood Restaurants, Franklin
- Secondary Schools, Franklin
- Security Brokers & Dealers, Franklin
- Senior Citizens Information & Services, Franklin
- Ship & Boat Building & Repairing, Franklin
- Shoe Stores, Franklin - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Franklin
- Sleep Doctors, Franklin - Specialists, Physicians & Surgeons (Sleep Medicine)
- Snack Foods, Franklin
- Social Services & Welfare, Franklin
- Societies & Foundation Associations, Franklin
- Soul Food Restaurants, Franklin
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- Special Education & Care, Franklin
- Specialty Stores, Franklin
- Specialty Vehicle Rental & Leasing, Franklin
- Spiritual Church, Franklin
- Sporting Goods Stores, Franklin
- State Government, Franklin
- State Parks, Franklin
- Stationery & Office Supplies, Franklin
- Steel & Metal Goods, Franklin - Steel Distributors
- Steel Manufacturers, Franklin
- Stocks & Bond Brokers, Franklin
- Substance Abuse Clinics, Franklin - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Sugar Refiners, Franklin
- Sugar Retail, Franklin
- Surveyor Services, Franklin - Surveying Service
- Surveyors, Franklin
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